The Lancet reported about grass pollen injection immunotherapy for summer hay fever by Leonard Noon and John Freeman on June 11th 1911. After Noon’s death in 1913, Freeman continued the work expanding the practice of immunotherapy. In 1930 Freeman published the first rush immunotherapy protocol.

What followed was well written and cited but the beginnings were at St. Mary’s with Almroth Wright and his laboratories which were full swing trying to develop immunization. Blackley had shown previously that grass pollen had been causation in hay fever about 40 years before. His sister Dorothy Noon was the one that collected grass pollen for him. Noon confirmed that hay fever was the result of grass pollen before proceeding.

Shortly after Noon was diagnosed with Tuberculosis and chose bedrest, it was there that he wrote the paper on Allergen Immunotherapy.